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The practical impact on conclusions of three meta-analyses submitted to publication bias adjustment. |
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| Authors |
Topic |
Comparison |
Outcome |
Non-adjusted meta-analysis conclusion (transcription) |
Adjusted meta-analysis conclusion |
|
|
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| Hopkins 14 |
Antibiotic prophylaxis regimens for cesarean section |
Any single dose of systemic antibiotic versus any multiple dose |
Endometritis |
"There is no evidence from this meta-analysis to recommend multiple doses of antibiotics" |
Any single dose systemic regimen (pre, post or intra-operative) may be more effective than any multiple dose regimen |
| Hodnett 15 |
Continuous support for women during childbirth |
Continuous one-to-one intrapartum support versus usual care |
Cesarean birth |
"Women who had continuous, one-to-one support during labour were less likely to have a caesarean birth" |
Continuous support may not reduce the occurrence of cesarean birth comparing to usual care. |
| Cheng 16 |
Interventions for emergency contraception |
Mifepristone mid-dose (25–50 mg) versus low-doses (≤ 10 mg) |
Observed number of pregnancies |
"Although the overall meta-analysis shows fewer pregnancies with the mid-dose... when the analysis is limited to the five trials with adequate allocation concealment...this effect is no longer evident" |
Mifepristone mid-doses (25–50 mg) may not be more effective than low doses (≤ 10 mg) |
Souza et al. Reproductive Health 2007 4:3 doi:10.1186/1742-4755-4-3 |
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